Moreover, we recently published (43) a link between E2/ERa signaling in breast cancer and pluripotency-like reporgramming, pointing to a mechanism where SOX2 can promote non-genomic E2 signaling that leads to nuclear phospho-Ser118-ERa, which exacerbates genomic ER signaling in response to E2. This evidence concerns the gene ESR1 and breast carcinoma.