The anti-CD11a mAb markedly reduced COL1A2 mRNA transcription in normal fibroblasts stimulated by SSc CD4+ T cells and 5-azaC-treated CD4+ T cells, but the control IgG did not (P <0.01 and P <0.01, respectively; Figure 5A,B). This evidence concerns the gene COL1A2 and systemic sclerosis.