Suppression of DSP expression responsible for human ARVC, leads to nuclear localization of PG and to suppression of canonical Wnt/beta-catenin-Tcf/Lef1 signaling in cultured atrial myocytes and in mouse hearts (Sen-Chowdhry et al., 2005). This evidence concerns the gene CTNNB1 and Arrhythmogenic right ventricular dysplasia.