Hong et al. (2005) showed that expression of Ffar2 was significantly greater in white adipose tissues of mice with HFD-induced obesity than in normal chow-fed mice. Further, they showed that SCFAs suppressed isoproterenol-induced lipolysis in a concentration-dependent manner in 3T3-L1-derived adipocytes (Hong et al., 2005). Additionally, Ge et al. (2008) demonstrated that these effects were dependent on FFAR2 using Ffar2 KO mice. The gene discussed is FFAR2; the disease is obesity due to melanocortin 4 receptor deficiency.