COX-2 and one of its products, prostaglandin E2, have been involved in LPS- and interleukin (IL)1β-induced anorexia which is inhibited by COX-2 but not COX-1 inhibitors (Lugarini et al., 2002; Asarian and Langhans, 2010). The gene discussed is PTGS2; the disease is Anorexia.