On the other hand, there is evidence that endogenous corticosterone protects from inflammation-induced behavioral changes, given that behavioral changes due to LPS, IL-1β, and viral infection are enhanced by adrenalectomy or glucocorticoid antagonists (Goujon et al., 1995; Johnson et al., 1996; Pezeshki et al., 1996; Silverman et al., 2007; Wang et al., 2011). Here, IL1B is linked to viral infectious disease.