PTGS2 and colitis: COX-2 has been involved in LPS- and IL1β-induced anorexia, Asarian and Langhans (2010), which is also a symptom of IBD, of TNBS acid-induced colitis in rats and of DSS-induced colitis in mice (Gee et al., 1985; Ballinger et al., 2000; DeBoer et al., 2010).