Single nucleotide polymorphism in BDNF val66met allele is implicated with increased risk for schizophrenia, and cognitive impairments and is mediated at least in part by activity-dependent trafficking and/or secretion of BDNF (Lu and Martinowich, 2008; Li and Pozzo-Miller, 2014). The gene discussed is BDNF; the disease is Cognitive impairment.