Genes regulating glycogen metabolism (Gys2), glycolysis (Aldob and Eno2) and glucose transport (Slc2a2) were all affected by Tcf7l2 silencing in the hepatoma cells, suggesting that TCF7L2 activity is an important determinant of carbohydrate metabolism overall in the liver. The gene discussed is SLC2A2; the disease is hepatocellular carcinoma.