In addition to reported upregulation in breast carcinomas[16, 23], high level of CUL4A expression was also found in squamous cell carcinoma of the esophagus[31], Adrenocortical carcinoma[32], childhood medulloblastoma[33], hepatocellular carcinomas[17], malignant pleural mesothelioma[20] and prostate cancer[22]. The gene discussed is CUL4A; the disease is hepatocellular carcinoma.