NGF treatment of either acutely isolated rat adrenal medulla cells which express K2P3.1 channels or a rat adrenal medulla cell line from a pheochromocytoma (PC12 cells) which express both K2P3.1 and K2P9.1 resulted in decreased functional expression of K2P3.1 and increased cytosolic expression of the channel [74]. Here, KCNK3 is linked to hereditary pheochromocytoma-paraganglioma.