Our laboratory has previously shown a positive feedback mechanism in the control of the AT1R, where Ang II through the AT1R evokes a transcriptional upregulation of the AT1R, a clearly pathological event that may contribute to sympatho‐excitation and worsening of the CHF state (Liu et al. 2008; Mitra et al. 2010; Haack et al. 2012). The gene discussed is AGTR1; the disease is congestive heart failure.