The discrepancy in results between acute and chronic exercise may be due to the long time span of a chronic intervention, in which multiple weak factors can influence the lipid stores like obesity/fat percentage, training status, the type, intensity and duration of exercise, muscle fiber type, sex, age, plasma free fatty acids (FFA), leptin/fat store memory fix point, basal fat oxidation, metabolic flexibility, intrinsic lipid droplet (LD) limits, LD subpopulations, glycogen repletion priority, and genetic as well as epigenetic factors. Here, LEP is linked to obesity disorder.