CDH1 and metastatic malignant neoplasm in the lymph nodes: In addition, the integrity of E-cadherin/β-catenin complex was lost in the unfavourable categories of these clinicopathologic variables: tumor size (>3 cm) (p = 0.006), presence of lymph node metastasis (p = 0.0001), presence of necrosis (p = 0.0001), higher mitotic index (p = 0.0001) and tobacco consumption (p = 0.0001).