Moreover, laryngeal cancers with TFG total score ≥14 points, deep invasion (3–4 points), and disseminated growth (3–4 points) were noted to have significantly higher HIF-1α gene level compared to less invasive tumors (p < 0.001, p < 0.001, and p < 0.001, respectively). The gene discussed is HIF1A; the disease is laryngeal carcinoma.