The aim of this study was to determine the messenger RNA (mRNA) expression of SLC2A1 and SLC2A3 genes coding GLUT isoform 1 (GLUT1) and isoform 3 (GLUT3), as well as the regulatory HIF-1α gene and the levels of their corresponding proteins, to investigate their influence on tumor aggressiveness and patient prognosis in squamous cell laryngeal cancer. This evidence concerns the gene SLC2A1 and neoplasm.