The aim of this study was to determine the messenger RNA (mRNA) expression of SLC2A1 and SLC2A3 genes coding GLUT isoform 1 (GLUT1) and isoform 3 (GLUT3), as well as the regulatory HIF-1α gene and the levels of their corresponding proteins, to investigate their influence on tumor aggressiveness and patient prognosis in squamous cell laryngeal cancer. Here, SLC2A3 is linked to neoplasm.