LysM-Cre, combined with a GFP reporter, has also been employed to track loss of KC membrane integrity following Ad5 adenovirus infection,35 and in further gene deletion studies.36–38 Using LysM-Cre to knock down peroxisome proliferator-activator receptor gamma (PPAR-γ) was shown to reduce macrophage expression of both PPAR-γ isoforms to <25% of baseline and, in both acute and chronic CCl4-induced liver injury, these mice demonstrated increased liver injury and fibrosis.38 Here, PPARG is linked to adenoviridae infectious disease.