Although no other significant differences were observed in patients with and without anti-PLA2R antibodies, anti-PLA2R antibody positive iMN patients had higher urinary protein levels (p = 0.06) and a higher rate of nephrotic syndrome (urinary protein ≥3.5 g/day and serum albumin ≤3 g/dL, p = 0.08) and a lower serum total protein level (p = 0.06) than the anti-PLA2R antibody negative iMN patients. This evidence concerns the gene PLA2R1 and nephrotic syndrome.