Anti-PLA2R antibodies were positive in 61 % (33 of 54) of the iMN patients with nephrotic syndrome (UP ≥3.5 g/day and serum albumin ≤3.0 g/dL) and in 43 % (20 of 46) of iMN without nephrotic syndrome. This evidence concerns the gene PLA2R1 and nephrotic syndrome.