With this in mind, we assessed key transiently activated neural transcription factors (MATH1, NHLH1), and other temporally activated genes (NEUROD1, NHLH2, NFIB, LPPR4, DPYSL3, NEUROD2) expressed throughout granule neuron differentiation, in the medulloblastoma subgroups (Fig. 3c). Here, PLPPR4 is linked to medulloblastoma.