IL15 and T-cell large granular lymphocyte leukemia: In this regard, it is interesting to note that blocking the effects of IL-15 has been suggested as therapy in other situations where IL-15 is thought to drive the pathology as shown for various autoimmune diseases including rheumatoid arthritis and multiple sclerosis, but also the rare lymphoproliferative T-cell large granular lymphocytic leukemia [56]–[58].