26, 28, 29, 30, 31, 32 Moreover, BIS, also known as BAG3, has been implicated in the invasive and metastatic phenotypes of cancers, suggesting a possible role as a prognostic marker.33, 34, 35, 36 Although the anti-apoptotic function of BIS appears to largely contribute to tumor expansion and resistance to chemotherapy, the impact of BIS on the inhibition of senescence and subsequent tumor progression has not been elucidated. This evidence concerns the gene BAG3 and neoplasm.