Recently, sequential systemic proteomic analyses demonstrated that BIS and STAT3 were enrolled in the lists of 14-3-3ζ interactome and, reversely, 14-3-3ζ was recognized as a BIS-binding protein in the BIS interactome.44, 45 The importance of 14-3-3ζ and BIS was described in promoting aggresome formation.46 Moreover, 14-3-3ζ was reported to interact with STAT3 in multiple myeloma cells.47 Based on these previous findings, we tested the possibility that 14-3-3ζ is involved in the coupling of BIS and STAT3 with respect to the regulation of senescence. This evidence concerns the gene STAT3 and plasma cell myeloma.