SIM+MET treatment reduces C4-2B cell viability >90% by 96 h.10 SIM treatment was shown to induce cancer cell death by apoptosis, necrosis, or autophagy,13, 14, 15 and MET treatment leads to apoptosis or autophagy in prostate and other cancers.16, 17 The mode of cell death activated by combination SIM+MET in metastatic CRPC cells has not been elucidated, but is important to define prior to pursuing potential clinical application. The gene discussed is MET; the disease is cancer.