NFKB1 and cancer: This is consistent with previous findings that cross talk between β-catenin/TCF and NF-κB has a pivotal role in regulating the expression of their targeted genes.14, 15, 16 Furthermore, p65-dependent effects of BITC are not observed in p53-positive cancer cells (Figures 4a,5d and e) and thus are presumably not observed in normal tissue.