To our knowledge, this is the first report that shows its antiproliferation activity is sensitized by NF-κB. In human lung cancer A549 cells, both BITC and SFN exert their anticancer effects through binding to tubulin.28 However, in HT-29 cells, the nuclear translocation of p65 was induced by BITC (Figure 2b) but not by SFN (Figure 2d). The gene discussed is NFKB1; the disease is lung cancer.