CCND1 and colorectal cancer: Accumulation of the overexpressed β-catenin in nucleus activates the expression of its target genes such as cyclin D1, which is required for the G1/S transition in the cell cycle.5 This transition contributes to cell proliferation and tumorigenesis in colorectal cancers.6, 7, 8 Thus, targeting the β-catenin/cyclin D1 pathway is a promising strategy for preventing the onset of colorectal cancer.