An epidemiological study suggested that patients with a combination of cyclin D1 A870G polymorphism, low dietary ITC consumption and high-activity glutathione S-transferase profile have an increased risk of colorectal cancer.44 In colorectal cancer model Apc (Min/+) mice, phenethyl ITC, a dietary ITC with an aromatic ring like BITC, decreased cyclin D1 expression and polyposis formation but not β-catenin total expression.45 These findings strongly support the idea that dietary aromatic ITCs elicit chemopreventive effects, possibly by regulating cyclin D1 expression in colorectal cancers. This evidence concerns the gene HPGDS and colorectal cancer.