CCND1 and colorectal cancer: An epidemiological study suggested that patients with a combination of cyclin D1 A870G polymorphism, low dietary ITC consumption and high-activity glutathione S-transferase profile have an increased risk of colorectal cancer.44 In colorectal cancer model Apc (Min/+) mice, phenethyl ITC, a dietary ITC with an aromatic ring like BITC, decreased cyclin D1 expression and polyposis formation but not β-catenin total expression.45 These findings strongly support the idea that dietary aromatic ITCs elicit chemopreventive effects, possibly by regulating cyclin D1 expression in colorectal cancers.