Resveratrol (RSV), apotent chemosensitising polyphenol, might share common properties withchemotherapeutic drugs through its indirect DNA-damaging effects reported invitro. In this study, we investigated how RSV exerts its anticancer effectsin models of colon cancer with a particular emphasis on the DNA-damage response (DDR;PIKKs-Chks-p53 signalling cascade) and its cellular consequences. This evidence concerns the gene TP53 and malignant colon neoplasm.