MiR-194 has been characterized as a regulatory mediator in liver fibrogenesis and metabolism of hepatic cholesterol and bile acid.24 In addition, miR-194 inhibits chondrogenic differentiation of human adipose-derived stem cells by targeting Sox5,25 and suppresses osteosarcoma cell proliferation and metastasis in vitro and in vivo by targeting CDH2 and IGF1R.26 These findings suggest that miR-194 might be a putative target molecule for regulating metabolic and bone disease. This evidence concerns the gene CDH2 and osteosarcoma.