Globoid cell leukodystrophy (GLD), also known as Krabbe disease, is a childhood leukodystrophy triggered by mutations in the galactocerebrosidase (GALC) gene; the physio-pathological hallmarks of GLD are progressive demyelination, reactive astrocytosis and microgliosis.1 GALC is a lysosomal enzyme essential for the normal catabolism of galacto-lipids, including galactosyl-ceramide and galactosyl-sphingosine (psychosine, PSY). Here, GALC is linked to Krabbe disease.