Sub-cellular raft fractions resulted enriched in cholesterol as well, indicating a change in the overall raft composition during GLD progression.4 Rafts are tightly linked to Ca2+ regulation: the activation of store-operated Ca2+ influx is modulated by lipid rafts, and the transient receptor channels TRPC1 and TRPC6 are involved in raft-mediated Ca2+ influx.41 A possible scenario is that the PSY-induced raft disruption can also change the overall membrane Ca2+ permeability and/or determine an active Ca2+ influx mediated by channels anchored to lipid rafts. The gene discussed is TRPC6; the disease is Krabbe disease.