Figure 6a shows that lungadenomas in V600EBRAF mutant mice, which have been shown to consistmostly of senescent cells,5 are positivefor DEP1, STX4 and B2MG expression, whereas they are only weakly positive forNTAL. Of note, the level of expression of these markers was comparable to that ofp16, a commonly used senescent marker. Non-adenoma cells were negative for allmarkers (data not shown). Moreover, human naevi, which are rich in senescentmelanocytes,9 also showed positivestaining for the same markers, especially DEP1 and STX4 (Figure6b and Supplementary Figure 3B). Here, STX4 is linked to adenoma.