Recent studies have shown thatlarge macromolecular cargos, proteins and peptides can be deliveredintracellularly if conjugated to permeation peptides that are derived fromtranscriptional transactivator (Tat)-basic domains.76, 77 Hotchkiss etal.78 have shown that a Tat-BH4conjugate had a high potent effect on decreasing sepsis-induced lymphocyteapoptosis in vivo in the mouse CLP model. The gene discussed is TAT; the disease is Sepsis.