IL18 and Sepsis: The study also revealed that caspase-7, a direct substrate of caspase-1,did not have any deleterious role in sepsis, in contrast to what was suggestedpreviously.39 Even indeed, not onlywere the caspase-7−/− mice sensitive to LPS doses,IL-1β/IL-18/caspase-7 triple knockout mice were notadditively protected in comparison with IL-1β/IL-18 double knockoutmice.41 The controversies that havebeen aroused might be due to the differences in mice genetic background, experimentalsetup, source and the doses of LPS to induce sepsis among individual labs.