6 Similarly, inanother sepsis study the mitochondrial pathway was shown to be activated by BID, apro-apoptotic member of the B-cell lymphoma-2 (Bcl-2) family protein.35 Immunohistochemical studies of the spleen ofpatients who died of sepsis showed findings that are consistent with activation ofthis pathway.36, 37. The gene discussed is BCL2; the disease is Sepsis.