Theyhave also revealed that apart from the polycaspase inhibitor, zVAD.fmk, theselective caspase-3 inhibitor L-826,791 (M-791) has beneficial effects in sepsisthrough the inhibition of lymphocyte apoptosis.9 Similarly, in a recent study of a CLP model of sepsisusing the VX-166, a broad spectrum caspase inhibitor showed beneficial effects forthe treatment of sepsis.59 VX-166 showedpotent anti-apoptotic and anti-inflammatory effects by inhibiting the release ofIL-1β and IL-18 through attenuating the caspase-1 pathway insepsis. This evidence concerns the gene IL18 and Sepsis.