The study also revealed that caspase-7, a direct substrate of caspase-1,did not have any deleterious role in sepsis, in contrast to what was suggestedpreviously.39 Even indeed, not onlywere the caspase-7−/− mice sensitive to LPS doses,IL-1β/IL-18/caspase-7 triple knockout mice were notadditively protected in comparison with IL-1β/IL-18 double knockoutmice.41 The controversies that havebeen aroused might be due to the differences in mice genetic background, experimentalsetup, source and the doses of LPS to induce sepsis among individual labs. This evidence concerns the gene CASP1 and Sepsis.