In line withthis statement Duprez et al.53 showed that the mice pre-treatedwith zVAD.fmk did not show protection against TNF-induced SIRS, unless Nec-1 wasadministrated into them to get better survival outcome, which therefore correspondsto the previous finding by Cauwels et al.81 showing co-administration of zVAD-fmk sensitized mice toTNF-induced SIRS. This evidence concerns the gene TNF and systemic inflammatory response syndrome.