Towards linking tothe caspases involvement into this RIPK-dependent cellular necrosis in sepsis, theyhave noticed that RIPK1- and RIPK3-dependent necroptosis in cells in sepsis could beinhibited by caspase-8, but not by the executioner caspases, caspase-3 and-7.53 Nevertheless, Wu etal.18 found discrepancy with theabove report mentioning that neither MLKL nor RIPK3 deficiency could protect againstpolymicrobial sepsis in mice. This evidence concerns the gene RIPK1 and Sepsis.