Although it is likely that the blocking of cellular pyroptosis by inhibitingcaspase-1 could be a promising therapeutic tool in sepsis, however, the recent workby Vandenabeele and co-workers41 showedthat the caspase-1- and its amplifier-, caspase-11-deficient mice did not conferprotection against a lethal TNF or cecal ligation and puncture (CLP)-induced sepsis,unless simultaneous targeting of IL-1β and IL-18 to get rid of sepsisseverity. The gene discussed is TNF; the disease is Sepsis.