We found a strong positive association in controls between rs4998386-T and heavy coffee drinking (OR = 1.48, 95% CI = 1.23, 1.78, p = 3×10−5), thus suggesting that GRIN2A-rs4998386-T is associated with an increased likelihood of drinking coffee among persons free of PD. The gene discussed is GRIN2A; the disease is Parkinson disease.