Notably, a high viral load of DENV infection alone, as demonstrated by plaque assays (P<0.001; Figure 6B), significantly (P<0.001) induced IL-10 production (Figure 6C) in a multiplicity of infection (MOI)-dependent manner, although phosphorylation of PKB at Ser473 and GSK-3β at Ser9 was not increased (Figure 6D). This evidence concerns the gene GSK3B and infection.