DDX41 and infection: The generation of antibodies (Abs) against the DENV E protein is fundamental for the host defense; however, such immune responses may increase the risk of developing DHF/DSS upon re-infection, primarily due to the canonical effects of antibody-dependent enhancement (ADE) – a phenomenon in which non-neutralizing anti-E Abs cross-react with the heterogeneous serotypes of DENV and facilitate their binding with Fcγ receptor-bearing cells to cause severe infection [20].