Specifically, the 8 most highly upregulated genes following YFV-17D infection were associated with innate immune response to infection: LOC699418 (eosinophil lysophospholipase-like), RTD1A (theta defensin 1 α precursor), MNPA1 (α defensin 1 α), CRISP-3 (cysteine-rich secretory protein 3), IFIT3 (interferon-induced protein with tetratricopeptide repeats 3), RSAD2 (radical S-adenosyl methionine domain containing 2-IFN induced gene) and CPA3 (mast cell secreted carboxypeptidase A3). This evidence concerns the gene CRISP3 and infection.