The ROC curves suggest that PTX3 (area under the curve (AUC) 0.913 [95% CI 0.837–0.990]) has better sensitivity and specificity for predicting CTEPH than either BNP (AUC 0.863 [95% CI 0.793–0.945]) or CRP (AUC 0.6444 [95% CI 0.4714–0.8174]). This evidence concerns the gene PTX3 and chronic thromboembolic pulmonary hypertension.