CASP9 and ovarian cancer: However, immunoblotting revealed Caspase-9 was not activated upon paclitaxel treatment in SKOV-3 and SKOV-3-TR cells, indicating that both paclitaxel and FOXM1 silencing effect cell death primarily through enhancing mitotic catastrophe rather than apoptosis in ovarian cancer cells, which commonly have dysfunctional p53 pathway.