Notably, there also appeared to be only marginal increases in the expression of cleaved Caspase-9 and Caspase-7 in both SKOV-3 and SKOV3-TR upon paclitaxel treatment, suggesting that apoptosis may not be the predominant mechanism of inducing cell death in these ovarian carcinoma cells. The gene discussed is CASP9; the disease is ovarian carcinoma.