The result showed there was an increased number of multi-nucleated cells (arrow) in ovarian cancer cells with FOXM1 knockdown (P = 0.03 and 0.01, respectively) (Fig. 4), suggesting FOXM1 depletion significantly enhanced paclitaxel-mediated mitotic catastrophe in both SKOV-3 and OVCAR3. Here, FOXM1 is linked to ovarian carcinoma.