LEP and Cachexia: However, median leptin levels did show substantial intra-day variation; 2.4 (range, 1.0 to 9.8) ng/ml and 1.1 (0.8 to 4.4) ng/ml at 6:30 AM and 11:30 respectively for patients with cachexia (p = 0.003), and 3.95 (2.0 to 9.9) ng/ml and 3.1 (1.5 to 7.8) ng/ml at 6:30 AM and 11:30 respectively for those without cachexia (p = 0.03).