Fasting hormones, such as leptin and ghrelin; pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interferon gamma, and interleukin 6 (IL-6); insulin-like growth factor-1 (IGF-1); and the tumor-secreted proteolysis-inducing factor have all been implicated to some extent in cachexia development [6]–[9]. The gene discussed is LEP; the disease is Cachexia.