EGR4 and small cell lung carcinoma: Introduction of the siRNAs into SBC-5, SBC-3 and NCI-H1048 cells resulted in a significant reduction in the expression of the target genes accompanied by significant suppression of cell proliferation (Figure 5A–D, Figure S3), suggesting that these genes are also likely to play a crucial role in the proliferation of SCLC cells via EGR4 transcriptional activation.