Our previous studies in murine paracoccidioidomycosis have shown that the expansion of IL-17 producing cells is controlled by several pathogen recognition receptors (TLR-2, TLR-4, dectin-1) as well as the IL-1R and Toll adaptor protein, MyD88 [51], [52], [53], [54]. Here, IL1R1 is linked to paracoccidioidomycosis.