The evolutionary growth of cancer sounds impossible to tackle, but Vogelstein et al. have organized all of the known driver genes into 12 cancer cell-signaling pathways: RAS, PI3K, STAT, MAPK, TGF-β, DNA damage control genes, transcriptional regulation, chromatin modification, APC, HH, NOTCH, and cell cycle/apoptosis [14]. The gene discussed is PIK3CA; the disease is cancer.