Breakthroughs in whole genome sequencing (WGS) of cancer were evident when recurrent mutations were found in the active site of the cytosolic NADP + −dependent isocitrate dehydrogenase 1 gene (IDH1), first identified in glioma [7] and then in acute myeloid leukemia (AML) [8]. The gene discussed is IDH1; the disease is acute myeloid leukemia.