It isnotable that orthologs of three key regulators in our network—Hog1, Cdc14, andCK2—have all been implicated in regulating the mammalian tumor suppressor p53 (Meeket al, 1990; Bulavin et al,1999; Li et al, 2000), which controls the growth/survival/apoptosis decision in human cells and ismutated in many human cancers (Carvajal & Manfredi, 2013). This evidence concerns the gene CDC14A and cancer.