Entacapone was not associated with an increased risk of acute myocardial infarction, stroke, or death in elderly patients with PD [267].Entacapone is generally well tolerated, and no significant adverse events are reported [265].Entacopone induces a dose-dependent inhibition of COMT activity inerythrocytes and a significant decrease in the plasma levels of 3-O-methyldopa, indicating their effectiveness as COMT inhibitors [268]. Entacapone, inhibit dose dependently the COMT activity in erythrocyts [269-271].NO literature available on effect of medication or COMT inhibition on eryptosis. Here, COMT is linked to stroke disorder.