ANXA5 and anemia (phenotype): Amantadine (5.0 mM) immediately disordered the packing state of the outer lipid leaflet of membranes [297].RBCs express N-methyl D-aspartate (NMDA) receptors on their surface, but activation or inhibition of NMDA receptors on RBCs has no influence on their deformability and aggregability [298]. Side effects of amantadine include anemia and exposure of erythrocytes to amantadine increased [Ca2+] and triggered annexin V binding, suggesting that it may cause apoptosis[299].Amantadine causes fluidization of erythrocyte membranes and inhibits vesicle release [300].