TLR7 and neoplasm: Co-delivery of 3 M-052 (TLR7, TLR8 agonist) and CpG ODN via intratumoral injection has led to complete rejection of large tumors (colon cancer and melanoma) in murine models, while delivery of 3 M-052 or CpG ODN alone only reduced the tumor growth rate (Zhao et al., 2014).