In the study by Kasahar et al. [17], the pretreatment serum VEGF levels were measured in 95 patients with lung adenocarcinoma who received EGFR-TKI treatment, although patients presenting with a higher serum VEGF levels proved to have a poor tumor response, significantly shorter PFS and OS than patients with lower serum VEGF levels, these features did not independently determine OS in multivariate analysis. Here, EGFR is linked to neoplasm.