Our data demonstrate also that helminth infection, and especially multiple infections, are associated with a Th2 immune response (e.g. the production of Th2 cytokines by PBLs stimulated with helminth antigens and peripheral blood eosinophilia) but that such infections are associated with the upregulation of a regulatory network with an increase in unstimulated IL-10 production which could play a role in the suppression of immediate hypersensitivity reactions in the skin. Here, IL10 is linked to Increased total eosinophil count.