Helminth infection are believed to induce an immune response which is distinct from that produced in response to other chronic pathogens (e.g. protozoa, viruses and bacteria) in that chronic helminth infections and co-infections[1, 7, 31, 32] are characterized by a Th2 immune response in which various Th2 inflammatory markers such as eosinophilia and increased serum IgE levels are prominent. The gene discussed is IGHE; the disease is coinfection.