RNASE3 and asthma: When we considered the ECP levels insputum supernatants, we found that those levels were associated with poor asthmacontrol, further underscoring the fact that eosinophils play a role in thisequation.(28) However, despite expectations that patients with severe asthma would showhigher sputum ECP levels, Romagnoli et al.(21) observed no differences among groups of asthma patients, stratified byasthma severity, in terms of the sputum levels of ECP.