Conversely, in luminal breast cancer, GATA3 supports aspects of cancer progression through altered signal transduction of hormones and growth factors; increased proliferation and decreased apoptosis; and simultaneously, signaling prognosis associated with GATA3 expression [7],[74] may be a result of other processes, including upregulation of genes regulating chromosome integrity (BEGAIN, CEP70, HFM1). The gene discussed is GATA3; the disease is breast cancer.