Cluster 1 (Fig. 3B), which contained 460 genes, was positively correlated with the profiles of the TFs Arnt (aryl hydrocarbon receptor nuclear translocator), Myc and Pparg (peroxisome proliferator‐activated receptor gamma); and negatively correlated with the profiles of Hif1a (hypoxia‐inducible factor 1‐alpha) and Stat3 (signal transducer and activator of transcription 3); and enriched for pathways associated with DNA replication, cell cycle and systemic lupus erythematosus. The gene discussed is HIF1A; the disease is systemic lupus erythematosus.