Thus, 50% of B220+ cells were detected at a dose of A23187 around 50 nM for HPB-ALL cells, 100–130 nM for Jurkat cells, 275 nM for BW5147 and 600 nM for EL-4 cells (Figure 5, see B220 induction). The gene discussed is PTPRC; the disease is acute lymphoblastic leukemia.