However, recent global multicenter clinical trials, such as the Severe Asthma Research Program [13] and the European Network For Understanding Mechanisms of Severe Asthma [14], showed no correlation between asthma severity and levels of total and antigen-specific IgE, raising suspicion that IgE may not play a role in the deterioration of asthma control in patients with adult asthma. This evidence concerns the gene IGHE and asthma.