SOS1 and Noonan syndrome: In the absence of SH3BP2 mutation in an individual considered to have Cherubism, genetic screening for mutations in genes implicated in Noonan syndrome (PTPN11, SOS1, RAF1, KRAS, NRAS, and BRAF), NF1, and craniofacial cutaneous syndrome (BRAF, MAP2K1) should be undertaken [31].