HMGA1 and malignant colon neoplasm: To define the role of HMGA1 in intrinsic and acquired resistance to conventional and biological agents used in cancer therapy, we first analyzed the sensitivity of GEO colon carcinoma cells, showing a very low HMGA1 expression, and of GEO CR cells, expressing abundant HMGA1 levels (Figure 1A), to the antineoplastic drugs CTX and 5-fluorouracil (5FU), which are used to treat colon cancer [8].