Futhrermore, a number of studies have used LNCaP cells as a model for studying the progression from androgen-dependent to –independent/castrate resistant prostate cancer (AIPC/CRPC) state and support the hypothesis that continuous AR activity and signaling continues to be one of the most important mechanisms in CRPC [58], [59], [60], [61], [62]. This evidence concerns the gene AR and prostate carcinoma.