GOLGB1 and amyotrophic lateral sclerosis: Since disruption of the Golgi in neurons is a hallmark of many neurodegenerative diseases, including ALS [47], [48], we investigated the relationship of the inclusions to the Golgi, comparing their distribution with the one of two different Golgi markers, GM130, which is preferentially localized to the cis face of the Golgi ribbon, and giantin, which is present on Golgi vesicles.