The active form of vitamin D3, 1,25(OH)2D3, regulates calcium and bone homeostasis, immunity, and cellular growth and differentiation through direct binding to the vitamin D receptor (VDR), and has been demonstrated to inhibit the proliferation and to induce the differentiation of various types of malignant cells, including breast, prostate and colon cancers as well as myeloid leukemia cells [14], [15]. Here, VDR is linked to colonic neoplasm.