Thus, when combined with 1,25(OH)2D3, a RAR/RXR agonist (9cRA) and RAR agonists (ATRA and Am80), but not a RXR agonist (HX630), effectively induce differentiation of myeloid leukemia THP-1 and HL60 cells. The gene discussed is RARA; the disease is myeloid leukemia.