We therefore analyzed the relative ratios of Mcl-1L/Mcl-1S isoforms, which revealed a significant positive correlation with the poor overall survival of patients, implying that the low expression of Mcl-1S & Mcl-1ES in oral cancers is possibly insufficient to completely neutralize the high expression of anti-apoptotic Mcl-1L isoform. The gene discussed is MCL1; the disease is lip and oral cavity carcinoma.